A recent doctoral study by Oscar Liu at the University of Eastern Finland uncovers how low oxygen levels (hypoxia) impact gene expression and chromatin structure in cardiovascular tissues. His research highlights key molecular mechanisms that contribute to diseases such as heart attacks and atherosclerosis, identifying enzymes like KDM4B and KDM6B as potential therapeutic targets. Using advanced genomic techniques and a porcine heart model, the study demonstrates how hypoxia triggers changes in inflammation, mitochondrial function, and blood vessel repair, offering new insight into cardiovascular disease treatment strategies.
Source: University of Eastern Finland
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