Researchers from Göteborgs universitet and Uppsala universitet have identified eleven genetic regions that significantly influence the composition and function of the gut microbiota. The findings come from two coordinated international studies involving over 28,000 participants, making it the most comprehensive investigation to date of how human genetics shape gut bacteria. Previously, only two such genetic areas were known.
Several of the identified gene variants are linked to basic gut processes, such as nutrient absorption and interactions between gut cells and bacteria. Some variants are associated with increased risks for conditions like gluten intolerance, hemorrhoids, and cardiovascular disease.
The research relied on extensive biobanks, including Swedish population studies (SCAPIS-Malmö, SCAPIS-Uppsala, SIMPLER) and the HUNT study from Norway, providing one of the largest datasets in the world for gut microbiome research.
Source: Göteborgs universitet
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