Konstantin Klötzer, a physician at the Clinical Division of Nephrology and PhD student in the Molecular Medicine program at the Medical University of Graz, has published a first-author paper in the prestigious journal Nature Genetics during a research stay at the University of Pennsylvania.
The study, titled Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas, examines gene expression data from over one million cells and 140 samples, creating a detailed single-cell kidney atlas. The research team developed a new statistical method, “CellSpectra,” to detect molecular changes in cell functions and signaling pathways at the individual patient level. This approach could help tailor therapies and medications for patients with kidney diseases.
The method was also successfully applied to other conditions, including non-small cell lung cancer, demonstrating its potential beyond kidney research. Klötzer emphasised the goal of using modern single-cell RNA sequencing for diagnostics in complex diseases, advancing precision medicine.
Source: Medical University of Graz
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