At Charles University’s BIOCEV research center, biochemist Jiří Zahradník is leading advanced virology research aimed at predicting virus mutations before they emerge. Drawing on experience from the Weizmann Institute of Science, his team uses protein engineering and evolutionary methods to analyze thousands of potential mutations, including those not yet observed in nature.The goal is to identify high-risk mutations that could enable viruses—such as COVID-19—to spread or become more infectious. By anticipating these changes, the research could support the development of more effective vaccines and potentially prevent future pandemics before they begin.The work takes place in a high-security BSL-3 laboratory, where scientists safely study dangerous viruses like SARS-CoV-2 and HIV. Despite challenges such as funding gaps and institutional limitations, the research represents a major step toward proactive pandemic prevention.
Source: Charles University Magazine
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